Description

The CD27 antigen is a lymphocyte-specific member of the tumor necrosis factor receptor (TNFR) super family, which also includes nerve growth factor receptor, CD30, CD40, CD95 (Fas), CD120a, CD120b, CD134

(OX 40), and CD137.16,17 The CD27 antigen is also known as S152, T14, TNFRSF7, and Tp55.The CD27 antigen is present on most peripheral blood T lymphocytes and medullary thymocytes, and is upregulated upon activation with the release of a soluble form, 28–32 kDa.

Stability & Storage:

Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

Product Notices

1. This reagent has been pre-diluted for use at the recommended Volume per Test. We typically use 1 × 10^6 cells in a 100-μL experimental sample (a test).

2.Isotype control is not needed because the antibody has no Fc region.

3.For Research Use Only.

References

1.Baars PA, Maurice MM, Rep M, Hooibrink B, Van Lier RA. Heterogeneity of the circulating human CD4+ T cell population: further evidence that the CD4+CD45RA-CD27- T cell subset contains specialized primed T cells. J Immunol. 1995;154:17-25.

2.De Jong R, Brouwer M, Hooibrink B, van der Pouw-Kraan T, Miedema F, Van Lier RA. The CD27 subset of peripheral blood memory CD4+ lymphocytes contains functionally differentiated T lymphocytes that develop by persistent antigenic stimulation in vivo. Eur J Immunol. 1992;22:993- 999.